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Il a un haut degrГ© de sГ©lectivitГ© pour le sous-type D1DR des rГ©cepteurs de la dopamine D1 (stimulant du SNC). L'utilisation de modafinil par les personnes souffrant de dГ©pression et de pensГ©es suicidaires peut augmenter le risque d'aggravation de la dГ©pression ou des pensГ©es suicidaires. Le modafinil est plus efficace lorsqu'il est pris dans les 90 minutes prГ©cГ©dant un Г©pisode de sommeil, mais peut ГЄtre pris jusqu'Г huit heures avant le coucher. Il peut provoquer des nausГ©es, une dyspepsie et des vomissements. Le modafinil est un dГ©rivГ© du composГ© organique n-mГ©thylmorpholine et est l'un des nombreux dГ©rivГ©s de la n-mГ©thylmorpholine qui servent de stimulants du SNC. Modalert Canada Modafinil est un mГ©dicament sur ordonnance. La Food and Drug Administration (FDA) des Г‰tats-Unis n'a approuvГ© le modafinil pour aucune utilisation ni annoncГ© son intention de le faire. Si vous avez dГ©jГ pris ces mГ©dicaments, vous devrez peut-ГЄtre commencer Г prendre une dose plus faible au dГ©part. Le mГ©dicament parent et le mГ©tabolite ont tous deux une longue demi-vie plasmatique et une liaison aux protГ©ines modГ©rГ©e Г Г©levГ©e de 90 Г 94 %. Il est mГ©tabolisГ© par l'enzyme CYP3A4 du cytochrome P450, spГ©cifiquement en N-desmГ©thyl modafinil et N-dГ©sГ©thyl modafinil, le premier Г©tant le principal mГ©tabolite du m-modafinil racГ©mique et du R-modafinil. Le modafinil est une phГ©nГ©thylamine synthГ©tique, un stimulant et un coupe-faim. En Europe, des formes Г libГ©ration prolongГ©e de Modafinil sont Г©galement disponibles, qui ont des durГ©es variables. L'efficacitГ© et la toxicitГ© du modafinil ne sont pas claires. Il y a eu des utilisations hors AMM du modafinil dans de nombreuses conditions, y compris la dГ©pression, le TDAH, la sclГ©rose en plaques et le SSPT. Le modafinil est un coupe-faim prescrit comme mГ©dicament favorisant l'Г©veil et disponible uniquement sur ordonnance aux Г‰tats-Unis. La dose de mГ©dicament est gГ©nГ©ralement de 100 Г 200 mg. L'effet du modafinil est dose-dГ©pendant et dure plus longtemps que la durГ©e du stimulant. Si vous ressentez une sensibilitГ© particuliГЁre au Modafinil, vous pouvez essayer de rГ©duire la posologie.
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