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Modiodal
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Le modafinil n'est pas approuvГ© pour une utilisation comme activateur cognitif chez les personnes en bonne santГ© sans troubles du sommeil. Le modafinil est utilisГ© pour traiter les symptГґmes de la somnolence (p. Une dose de 120 mg et une dose de 180 mg sont disponibles. Dans les deux Г©tudes, aucun nouveau site rГ©cepteur n'a Г©tГ© identifiГ©. D'autres incluent l'armodafinil (Nuvigil, anciennement connu sous le nom de R-modafinil) et l'acide eugГ©roГЇque (Г©galement connu sous le nom de ST-91). Le modafinil peut Г©galement augmenter l'Г©veil chez les personnes travaillant de longues heures. On pense Г©galement que le modafinil amГ©liore la rГ©ponse du systГЁme nerveux Г la dopamine. Il doit ГЄtre pris pendant au moins trois semaines afin de dГ©terminer s'il est efficace pour amГ©liorer la somnolence diurne. Dans la narcolepsie, un trouble caractГ©risГ© par une somnolence diurne excessive, le mГ©dicament est utilisГ© pour prГ©venir les Г©pisodes de sommeil induits par la cataplexie (une attaque soudaine de faiblesse musculaire) et pour rГ©duire la somnolence diurne. Le modafinil stimule ces voies en augmentant le niveau du neurotransmetteur hypocrГ©tine. Le modafinil est prescrit pour traiter et prГ©venir les troubles du sommeil liГ©s au travail postГ© (SWSD). Ceci est probablement liГ© Г son action dans le systГЁme d'activation rГ©ticulaire ascendant dГ©pendant de la dopamine du cerveau. Le modafinil ne semble pas provoquer d'anxiГ©tГ© accrue ou d'autres effets secondaires stimulant le SNC comme des hallucinations. Modiodal Le modafinil a Г©galement Г©tГ© signalГ© comme ayant des propriГ©tГ©s anxiolytiques et antipsychotiques. Contrairement aux amphГ©tamines, il ne garde pas l'utilisateur Г©veillГ©. Modafinil contient de la phГ©nГ©thylamine, une substance qui peut produire des effets secondaires mentaux ou physiques. Il s'agit d'un mГ©dicament sympathomimГ©tique non amphГ©tamine qui ressemble Г une substance semblable Г un neurotransmetteur appelГ©e acГ©tylcholine. Le modafinil est excrГ©tГ© rapidement dans l'urine, le mГ©tabolite actif reprГ©sentant environ 90 % de l'Г©limination du mГ©dicament. Le modafinil peut avoir un effet paradoxal d'induction du sommeil, le principal effet "tГЄte" Г©tant la somnolence, avec peu de changement direct dans le sommeil, l'Г©veil ou les niveaux d'Г©nergie. Le modafinil manque Г©galement de nombreux potentiels de dГ©pendance et d'abus associГ©s Г d'autres stimulants tels que la cocaГЇne et l'amphГ©tamine. Le modafinil s'est avГ©rГ© moins dommageable pour le foie que d'autres mГ©dicaments de type amphГ©tamine chez les animaux. Le modafinil a Г©tГ© introduit en France en 1994 comme somnifГЁre diurne, puis utilisГ© aux Г‰tats-Unis en 1997 pour traiter la narcolepsie (Lafon C, Modafinil: a double blind study on schizophrenic and narcoleptic patients. Disponible en comprimГ©s de 25, 50, 100 et 200 mg et en comprimГ©s pelliculГ©s de 200 mg, Modafinil est gГ©nГ©ralement pris avec ou peu aprГЁs le petit-dГ©jeuner. Modafinil est fabriquГ© par Cephalon. Il n'est pas recommandГ© de le prendre dans l'heure qui suit le sommeil. Le modafinil est Г©galement un inhibiteur sГ©lectif de la recapture du neurotransmetteur inhibiteur acide gamma-aminobutyrique (GABA).
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