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Modiodal
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C'est un stimulant non amphétamine pour le SNC et n'est pas associé à l'augmentation de l'excitation qui est l'objectif d'autres stimulants tels que l'amphétamine. Ces sels sont appelés modafinil. Il a été développé à l'origine dans les années 1970 par le neuroscientifique français Michel Jouvet et les laboratoires Lafon pour le traitement de l'insomnie. Le modafinil est un stimulant du SNC, utilisé principalement comme traitement des troubles du sommeil tels que la narcolepsie et la privation de sommeil. La dose la plus efficace (interdite) est de 100 mg, bien que certaines personnes (légèrement) plus somnolentes seraient OK avec 50 mg, alors que les personnes moins endormies seraient OK avec 200 mg. Les effets indésirables courants comprennent les maux de tête, les troubles du sommeil, les nausées et les étourdissements. Le modafinil, nom chimique 1-(diphénylméthyl)-4-[1-(méthyl)propyl]pipérazine, est un médicament stimulant utilisé pour le traitement de la narcolepsie et des troubles du sommeil liés au travail posté. Modiodal Une dose maximale est de 400 à 800 mg par jour. Le modafinil augmente le temps nécessaire à une personne pour s'endormir ou rester endormie. Le modafinil est également utilisé pour réduire la somnolence diurne associée à une condition médicale, lorsqu'un médicament à action plus courte est préféré ou n'est pas toléré. Aux États-Unis, où le modafinil est une substance contrôlée de l'annexe IV, il a été commercialisé pour une utilisation hors AMM afin d'améliorer l'éveil. Cela inclut la libération de dopamine, bloquant le blocage de l'absorption de dopamine par l'adénosine. Dans l'hypothalamus, il augmente l'activité des neurones favorisant l'éveil. La narcolepsie touche environ 0,025 % de la population et se caractérise par des épisodes récurrents de réveil soudain et soudain, accompagnés d'une somnolence diurne excessive et de cataplexie. Le modafinil pour adultes est généralement pris une fois par jour avec un repas, au coucher et est généralement pris avec ou après le petit-déjeuner, avant de se coucher. Dans ce cas, il est pris par voie orale. Il a été rapporté que le modafinil augmentait la température corporelle, probablement par un effet sur le centre de thermorégulation du cerveau. Contrairement à l'amphétamine, le modafinil ne traverse pas la barrière hémato-encéphalique, empêchant ainsi la stimulation dopaminergique de type méthamphétamine. Comme l'amphétamine, c'est un stimulant non amphétamine.
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