Modiodal Drogue

[Modafinil Achat]

Shaw, a brevetГ© et a commencГ© Г  commercialiser une formulation de modafinil qui ne contenait que le composant dextroamphГ©tamine. Certaines Г©tudes suggГЁrent que des doses plus Г©levГ©es allant jusqu'Г  800 mg peuvent ГЄtre efficaces. C'est aussi un inhibiteur de la recapture de l'adГ©nosine, inhibant l'enzyme responsable de la dГ©gradation de l'adГ©nosine, qui inhibe l'Г©veil et est un facteur de troubles du sommeil. Le modafinil est principalement utilisГ© pour traiter la somnolence associГ©e Г  la narcolepsie et les troubles du travail postГ©. Dans une mГ©ta-analyse de 26 essais cliniques et 12 Г©tudes prГ©cliniques distinctes, il a Г©tГ© constatГ© que le modafinil augmentait l'Г©veil, mais pas la vigilance ou la performance chez les personnes atteintes de narcolepsie. Pour les travailleurs postГ©s, cela peut les aider Г  rester vigilants et Г  effectuer leur travail tout en facilitant le sommeil Г  la maison la nuit. Modiodal Drogue Le modafinil est gГ©nГ©ralement prescrit pour une utilisation Г  long terme. Il est classГ© comme substance contrГґlГ©e de l'annexe IV aux Г‰tats-Unis. Les Г©tudes de Jouvet avec le mГ©dicament ont commencГ© Г  la fin des annГ©es 1960. Le modafinil est un sГ©lectif norГ©pinГ©phrine inhibiteur de la recapture (NE), Г©galement appelГ© inhibiteur du transporteur de noradrГ©naline. Le modafinil amГ©liore l'Г©veil des patients souffrant de troubles du sommeil liГ©s au travail postГ© et rГ©duit la fatigue et la somnolence associГ©es Г  l'apnГ©e obstructive du sommeil.

---

L'action du modafinil dans les neurones est mГ©diГ©e par la stimulation des rГ©cepteurs de l'adГ©nosine A2A, les transporteurs de la dopamine et les rГ©cepteurs du N-mГ©thyl-D-aspartate. Il est administrГ© sous forme de gГ©lule dosГ©e Г  150 mg, 200 mg ou 300 mg, ou sous forme de suspension de 150 mg Г  600 mg. Le "NS" signifie nitro-sels, dans certains cas substituГ©s par un groupe hydroxylamine, indiquant que le mГ©dicament est un sel de l'amine libre, plutГґt qu'un dГ©rivГ© halogГ©no d'amine. Le modafinil est une poudre cristalline blanche Г  blanc cassГ© et se prГ©sente sous forme de comprimГ©s, de gГ©lules et de suspension. Il peut Г©galement augmenter les effets des mГ©dicaments qui agissent comme des antihistaminiques. La dopamine est un sous-type majeur de rГ©cepteurs de la dopamine qui est Г©galement largement distribuГ© dans le cortex cГ©rГ©bral, les zones sous-corticales, les ganglions de la base, le systГЁme limbique et le tronc cГ©rГ©bral. Modiodal Drogue Avant l'utilisation, les patients doivent ГЄtre examinГ©s pour les conditions susmentionnГ©es. Alors que la plupart des essais cliniques sur le modafinil ont utilisГ© 150 mg, certains chercheurs ont suggГ©rГ© que des doses plus Г©levГ©es de modafinil pourraient offrir des avantages accrus aux travailleurs postГ©s. Le modafinil fait Г©galement disparaГ®tre ses effets plus rapidement que certains autres mГ©dicaments disponibles sur le marchГ©.

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